Anti Varicella-zoster Virus (VZV/gE) Monoclonal antibody
Description: Varicella zoster virus (VZV, also known as human herpesvirus 3) is a ubiquitous alphaherpesvirus with a double-stranded DNA genome. VZV only naturally infects humans, with no animal reservoir; its main targets are T lymphocytes, epithelial cells and ganglia.Varicella-zoster virus (VZV) glycoprotein gE is the predominant viral cell surface molecule; it behaves as an Fc receptor for immunoglobulin G.
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Isotype: |
IgG |
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Species reactivity: |
Mouse |
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Production: |
Tissue culture |
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Purification: |
Protein A/G |
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Applications: |
ELISA, IFA, WB, FACS |
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Immunogen: |
Purified VZV antigen |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. |
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Clonality: |
Monoclonal |
Reference:
1. Heineman TC, Cunningham A, et al. (2019). Understanding the immunology of Shingrix, a recombinant glycoprotein E adjuvanted herpes zoster vaccine. Curr Opin Immunol. Aug;59:42-48.
2. Laing KJ, Ouwendijk WJD, et al. (2018). Immunobiology of Varicella- Zoster Virus Infection. J Infect Dis. Sep 22;218(suppl_2):S68-S74.
3. Zerboni L,Sen N, et al. (2014). Molecular mechanisms of varicella zoster virus pathogenesis. Nat Rev Microbiol. Mar;12(3):197-210.
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