Broadly neutralizing antibodies against influenza A viruses, Fully human, CR6261, diridavumab
Broadly neutralizing antibodies against influenza A viruses, Fully human, CR6261, diridavumab
Clone CR6261 Catalog#: A90004
Description: CR6261 (diridavumab) is fully human neutralizing monoclonal antibody against influenza A. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of HA1 and HA2. The antibody neutralizes the virus by blocking conformational rearrangements associated with membrane fusion. The CR6261 epitope identified here should accelerate the design and implementation of improved vaccines that can elicit CR6261-like antibodies, as well as antibody-based therapies for the treatment of influenza.
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Isotype: |
IgG1 |
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Species reactivity: |
Human |
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Production: |
Tissue culture |
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Purification: |
Protein A |
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Applications: |
Neutralization assay, In vivo protection etc. |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
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Clonality: |
Monoclonal |
Reference:
- Ekiert DC, et al. (2009). Antibody recognition of a highly conserved influenza virus epitope..Science. 2009 Apr 10;324(5924):246-51.
- Friesen RH, et al. (2010). New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets.PLoS One. 2010 Feb 8;5(2):e9106.
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