Anti Streptococcus Anginosus TMPC (S.anginosus-TMPC) Monoclonal Antibody
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Anti Streptococcus Anginosus TMPC (S.anginosus-TMPC) Monoclonal Antibody

A50573-100ug
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$699.00
$699.00

Anti Streptococcus Anginosus TMPC (S.anginosus-TMPC) Monoclonal Antibody

Anti Streptococcus Anginosus TMPC (S.anginosus-TMPC) Monoclonal Antibody

Clone HI573    Catalog#: A50573

Description: Streptococcus Anginosus TMPC protein, also known as the Tooth-Associated Protein C, is a key virulence factor of this bacterium, which is commonly found in the human oral cavity and is associated with the development of dental caries. TMPC is a glycoprotein that is secreted by Streptococcus Anginosus and is involved in several important processes related to the pathogenesis of dental caries. One of the main functions of TMPC is to bind to collagen, which is a major component of the extracellular matrix in the tooth's outer layers. This binding allows Streptococcus Anginosus to adhere to the tooth surface, forming a biofilm that is more resistant to clearance by saliva and other oral fluids. The biofilm also provides a protective environment for the bacteria, allowing them to thrive and produce acid, which is a major factor in the demineralization of tooth enamel. TMPC has also been shown to have a role in the regulation of the expression of other virulence factors in Streptococcus Anginosus, such as glucan-binding protein B (GBPB) and glucan-binding protein D (GBPD). These proteins are involved in the formation of glucan, a polymer that helps to cement the bacteria to the tooth surface and protects them from the host's immune system.

Isotype:

Mouse IgG

Species reactivity:

Mouse

Production:

Tissue culture

Purification:

Protein A/G

Applications:

ELISA, WB, IFA, IHC, CLIA, LFA, IP

Immunogen: 

Recombinant S. anginosus/TMPC Antigen

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.

Clonality:

Monoclonal

 

Reference: 
1. Levin, L. P., & Kolenbrander, P. E. (2001). Oral microbial ecology: the community as a whole. In J. B. Pecher (Ed.), Oral Microbiology and Immunology (pp. 1-20). Mosby.
2. Mäder, I. W., & Kolenbrander, P. E. (2003). Oral microbial communities and their interactions: a molecular approach. In D. C. Smith & H. H. Gold (Eds.), Oral Microbiology and Immunology (pp. 33-47). Mosby.
3. Brown, T. A., & Hajishengallis, G. (2015). Molecular mechanisms of Streptococcus mutans-induced dental caries. Journal of Dental Research, 94(12), 1550-1559.


Intended for research use only. Not for human, therapeutic, or diagnostic applications.


The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  
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