Anti Human 181 Position Phosphorylated Tau Protein (p-Tau181) Monoclonal Antibody
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Anti Human 181 Position Phosphorylated Tau Protein (p-Tau181) Monoclonal Antibody

A50563-100ug
Out of stock In stock
$699.00
$699.00

Anti Human 181 Position Phosphorylated Tau Protein (p-Tau181) Monoclonal Antibody

Anti Human 181 Position Phosphorylated Tau Protein (p-Tau181) Monoclonal Antibody

Clone HI563    Catalog#: A50563

Description: The phosphorylation of Tau at serine 181 (S181) is among the most commonly observed in AD and is considered a pathological hallmark of the disease. This phosphorylation event is thought to contribute to the destabilization of Tau-microtubule interactions and to promote the self-assembly of Tau into insoluble aggregates. The presence of phosphorylated Tau, including Tau181, in the brain is correlated with the degree of cognitive decline observed in AD patients. Tau181 is a target for diagnostic biomarkers because it is relatively easy to detect in cerebrospinal fluid (CSF) and brain tissue using immunological assays. The levels of phosphorylated Tau in CSF have been shown to correlate with the extent of neurodegeneration and can be used to distinguish between AD and other types of dementia. In research, the study of Tau181 and its role in the pathogenesis of AD is crucial for understanding the molecular mechanisms underlying the disease and for the development of potential therapeutic strategies aimed at preventing or reversing Tau pathology. Experimental approaches range from in vitro studies using recombinant Tau proteins to in vivo studies using animal models and post-mortem human brain tissue.

Isotype:

Mouse IgG

Species reactivity:

Mouse

Production:

Tissue culture

Purification:

Protein A/G

Applications:

ELISA, WB, IFA, IHC, CLIA, LFA, IP

Immunogen: 

Recombinant human p-Tau181 protein

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.

Clonality:

Monoclonal

 

Reference: 
1. Goedert, M., & Spillantini, M. G. (2006). A century of Alzheimer’s disease. Science, 314(5800), 777-781.
2. Lee, V. M., Goedert, M., & Trojanowski, J. Q. (1991). Neurodegenerative tauopathies. Neuron, 8(1), 15-35.
3. Mandelkow, E., & Mandelkow, E. M. (2012). Tau in Alzheimer’s disease and related tauopathies. Cold Spring Harbor perspectives in medicine, 2(10), a006247.


Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  
Copyright 2024. Humimmu LLC.  All Rights Reserved

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