Anti Human 181 Position Phosphorylated Tau Protein (p-Tau181) Monoclonal Antibody
Click to zoom in

Have Questions? | Bulk Inquiry?

Anti Human 181 Position Phosphorylated Tau Protein (p-Tau181) Monoclonal Antibody

Out of stock In stock

Anti Human 181 Position Phosphorylated Tau Protein (p-Tau181) Monoclonal Antibody

Anti Human 181 Position Phosphorylated Tau Protein (p-Tau181) Monoclonal Antibody

Clone HI563    Catalog#: A50563

Description: The phosphorylation of Tau at serine 181 (S181) is among the most commonly observed in AD and is considered a pathological hallmark of the disease. This phosphorylation event is thought to contribute to the destabilization of Tau-microtubule interactions and to promote the self-assembly of Tau into insoluble aggregates. The presence of phosphorylated Tau, including Tau181, in the brain is correlated with the degree of cognitive decline observed in AD patients. Tau181 is a target for diagnostic biomarkers because it is relatively easy to detect in cerebrospinal fluid (CSF) and brain tissue using immunological assays. The levels of phosphorylated Tau in CSF have been shown to correlate with the extent of neurodegeneration and can be used to distinguish between AD and other types of dementia. In research, the study of Tau181 and its role in the pathogenesis of AD is crucial for understanding the molecular mechanisms underlying the disease and for the development of potential therapeutic strategies aimed at preventing or reversing Tau pathology. Experimental approaches range from in vitro studies using recombinant Tau proteins to in vivo studies using animal models and post-mortem human brain tissue.


Mouse IgG

Species reactivity:



Tissue culture


Protein A/G




Recombinant human p-Tau181 protein


Store at +4°C short term (1-2 weeks). Store at -20°C long term.


PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.




1. Goedert, M., & Spillantini, M. G. (2006). A century of Alzheimer’s disease. Science, 314(5800), 777-781.
2. Lee, V. M., Goedert, M., & Trojanowski, J. Q. (1991). Neurodegenerative tauopathies. Neuron, 8(1), 15-35.
3. Mandelkow, E., & Mandelkow, E. M. (2012). Tau in Alzheimer’s disease and related tauopathies. Cold Spring Harbor perspectives in medicine, 2(10), a006247.

Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  
Copyright 2024. Humimmu LLC.  All Rights Reserved

Read More
Read Less

Please make sure that you follow below steps:

1/ Add your items of interest to the shopping cart by clicking Add to Cart.

2/ When you've finished shopping, click Check Out .You'll be asked to register if you are new to us.

3/ Fill in required shipping and payment information. We accept Credit Card and Paypal for online orders.

4/ Review your order, and then click Continue to Check Out.

5/ A confirmation email including tracking information of your order will be delivered to you through email within 24 hours. Please note that in case the item you are trying to purchase is not in stock, we will contact you directly to let you know the lead time.

If your company have credit reference sheet, please email ( to us, you are allowed to pay within 30 days after confirmation by our financial department.

If you don’t have credit reference sheet, please email ( us, and we will provide the Business Account Application Form for you.

Kindly remind that before applying for the payment terms, a full prepayment is required for the first time order from a valued new customer.

The cookie settings on this website are set to 'allow all cookies' to give you the very best experience. Please click Accept Cookies to continue to use the site.

Your cart