Anti Human T cell immunoglobulin ITIM domain (hTIGIT) Monoclonal Antibody
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Anti Human T cell immunoglobulin ITIM domain (hTIGIT) Monoclonal Antibody

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Anti Human T cell immunoglobulin ITIM domain (hTIGIT) Monoclonal Antibody

Anti Human T cell immunoglobulin ITIM domain (hTIGIT) Monoclonal Antibody

Clone HI530    Catalog#: A50530

Description: TIGIT (T cell immunoglobulin and ITIM domain), also known as WUCAM, Vstm3, VSIG9, is a member of the PVR/Nectin family. It consists of an extracellular immunoglobulin variable domain (lgV) structure domain, a 1-type transmembrane domain, and an intracellular domain with classical immunoreceptor tyrosine inhibitory motifs (ITIMs) and immunoglobulin tyrosine tails (ITTs). TIGIT is expressed in lymphocytes, especially in effector and regulatory CD4+T cells, follicular helper CD4+T cells, effector CD8+T cells, and natural killer (NK) cells. So far, it has been found that TIGIT can interact with CD155, CD112, and CD113, among which the interaction between TIGIT-CD155 is the strongest. CD155 is mainly expressed on the surface of immune cells such as DC cells, T cells, B cells, macrophages, etc. In non-immune cells such as kidneys, lungs, and pancreases, there are also a small number of expressions. CD112 is widely expressed on the surface of hematopoietic system cells and non-hematopoietic system cells, but CD113 is only expressed on the surface of non-hematopoietic system cells. What's worth noting is that CD155 and CD112 are highly expressed on the surface of many malignant tumors such as colorectal cancer and melanoma.


Mouse IgG

Species reactivity:



Tissue culture


Protein A/G




293T express recombination hTIGIT protein


Store at +4°C short term (1-2 weeks). Store at -20°C long term.


PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.




  1. Chauvin JM,Zarour HM.(2020).TIGIT in cancer immunotherapy. J ImmunotherCancer.Sep;8(2):e000957.
  2. Harjunpa H,Guillerey C.(2020).TIGIT as an emerging immune checkpoint. ClinExp Immunol.May:200(2):108-119.
  3. Annese T, Tamma R, et al.(2022). Update in TIGIT Immune-Checkpoint Role inCancer.Front Oncol.May 17:12:871085.

Intended for research use only. Not for human, therapeutic, or diagnostic applications.

The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  

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