Anti Human Pregnancy-Associated Plasma Protein A (hPAPP-A) Monoclonal Antibody
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Anti Human Pregnancy-Associated Plasma Protein A (hPAPP-A) Monoclonal Antibody

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Anti Human Pregnancy-Associated Plasma Protein A (hPAPP-A) Monoclonal Antibody

Anti Human Pregnancy-Associated Plasma Protein A (hPAPP-A) Monoclonal Antibody

Clone HI472    Catalog#: A50472

Description: Placental-associated plasma protein A (PAPP-A) is a metalloproteinase that belongs to the zinc finger family. Its main substrate is insulin-like growth factor binding protein 4 (IGFBP-4). This cleavage leads to the release of bound IGF, which plays an important role in promoting cell differentiation and proliferation. After pregnancy, embryonic trophoblast cells synthesize large amounts of PAPP-A and release it into the peripheral blood of both the mother and the fetus. The cumulative concentration in the mother's blood increases nearly 100 times, but pathological pregnancies can cause a sudden decrease in content. PAPP-A was first discovered in pregnant women's serum as a marker for early screening of Down syndrome during pregnancy and as a marker for unstable atherosclerotic plaques.



Mouse IgG

Species reactivity:



Tissue culture


Protein A/G




293F express recombinant hPAPP-A protein


Store at +4°C short term (1-2 weeks). Store at -20°C long term.


PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.




  1. Zhong O,Chu H,et al.(2022). Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.Cell Discov.Dec22:8(1):137.doi:10.1038/s41421-022-00502-2.

  2. Jepsen MR, Klaverpris S, et al. (2016). The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated bystanniocalcin-1 and -2 during human ovarian follicle development, HumReprod.Apr;31(4):866-74.di:10.1093/humrep/dew013

Intended for research use only. Not for human, therapeutic, or diagnostic applications.

The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  

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