Anti-Human PD-1xCTLA-4 Bispecific Antibody
Click to zoom in

Have Questions? | Bulk Inquiry?

Anti-Human PD-1xCTLA-4 Bispecific Antibody

Out of stock In stock

Anti-Human PD-1xCTLA-4 Bispecific Antibody

Clone: Vudbio                              Catalog#: AB5318


CTLA-4, also known as CD152, is the first immune checkpoint protein successfully targeted by ipilimumab. CTLA-4 is a transmembrane glycoprotein that binds to CD80 (B7-1) and CD86 (B7-2) proteins on APCs. CTLA-4 acts as a ‘off’ switch when bound to its ligands. PD-1, also known as CD279, primarily regulates effector T cell activity within tissues and tumors, rather than regulating T cell activation in lymphoid organs. PD-1 is a cell surface receptor that inhibits T cell proliferation and cytokine production (IFN-γ, IL-2, etc.), and reduces T cell survival by interacting with its ligands PD-L1 and PD–L2.








Human IgG1(N208D/E233P/L234V/L235A/G236Del/S267K/Q295E/L368D/K370S/N384D/Q418E/N421D/M428L/N434S)-kappa

Alternative Name:

XmAb-20717,cytotoxic T-lymphocyte-associated protein 4, CD152;programmed cell death 1, PD1, PD-1, CD279

Recommend Isotype Controls:


Recommended Dilution Buffer:

ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives.




PBS, pH 7.4,Contains no stabilizers or preservatives


<1EU/mg ,Determined by LAL gel clotting assay


>95% Determined by SDS-PAGE


0.2 μM filtered

Expression System:



Protein A




2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage.

Protocol Information:

Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment.


Intended for research use only. Not for human, therapeutic, or diagnostic applications.

The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  

Copyright 2023. Humimmu LLC.  All Rights Reserved

Read More
Read Less

Please make sure that you follow below steps:

1/ Add your items of interest to the shopping cart by clicking Add to Cart.

2/ When you've finished shopping, click Check Out .You'll be asked to register if you are new to us.

3/ Fill in required shipping and payment information. We accept Credit Card and Paypal for online orders.

4/ Review your order, and then click Continue to Check Out.

5/ A confirmation email including tracking information of your order will be delivered to you through email within 24 hours. Please note that in case the item you are trying to purchase is not in stock, we will contact you directly to let you know the lead time.

If your company have credit reference sheet, please email ( to us, you are allowed to pay within 30 days after confirmation by our financial department.

If you don’t have credit reference sheet, please email ( us, and we will provide the Business Account Application Form for you.

Kindly remind that before applying for the payment terms, a full prepayment is required for the first time order from a valued new customer.

The cookie settings on this website are set to 'allow all cookies' to give you the very best experience. Please click Accept Cookies to continue to use the site.

Your cart