Anti-Human IL-4/IL-13/TSLP trispecific Antibody, clone: tilrekimig, Ships in 3-5 Weeks
Anti-Human IL-4/IL-13/TSLP trispecific Antibody, clone: tilrekimig
Clone: tilrekimig Catalog#: N25052
Description:
Tilrekimig is a immunoglobulin trispecific antibody that targets IL-4, IL-13 and TSLP.
A key Th2 cytokine produced by T cells and mast cells, IL-4 drives B cell class-switching to IgE, promotes M2 macrophage polarization, and mediates anti-parasitic and allergic responses. It signals through the IL-4Rα/γc receptor complex. Closely related to IL-4, IL-13 shares the IL-4Rα receptor subunit and contributes to allergic inflammation, airway hyperresponsiveness, and tissue fibrosis. It directly acts on epithelial cells and smooth muscle, enhancing mucus production and remodeling. TSLP (Thymic Stromal Lymphopoietin) is a cytokine that stimulates monocytes to release T-cell-attracting chemokines, enhances the maturation of CD11c+ dendritic cells, directly activates mast cells, potentially triggering allergic inflammation and may exhibit antimicrobial properties in oral and skin mucosal barriers.
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Reactivities: |
Human |
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Target: |
IL-4/IL-13/TSLP |
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Clone: |
tilrekimig |
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Isotype: |
immunoglobulin (L-kappa-H-gamma1 (_L-VH-G1(CH1-h))_L kappa)_(H-gamma1_L-lambda2) |
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Alternative Name: |
interleukin 4, IL-4/ interleukin 13, IL-13/ Thymic Stromal Lymphopoietin |
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Recommended Dilution Buffer: |
PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Purification: |
Protein A |
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Clonality: |
trispecific |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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