Anti-Human IL-31RA Monoclonal Antibody
Anti-Human IL-31RA Monoclonal Antibody
Clone: Nembio Catalog#: AB5311
Description:
IL-31 is a tetrahelical cytokine discovered by Dillon et al. in 2004, which belongs to the IL-6 cytokine family but has lower homology with IL-6 cytokine family. It is mainly secreted by activated CD4+ T lymphocytes, especially activated Th2 cells, mast cells, monocytes/macrophages, and dendritic cells. In addition to IL-6 and IL-31, this family also includes IL-11, IL-27, oncostatin, leukemia inhibitory factor, ciliary neurotrophic factor, and cardiotrophin-like factor. The main target sites of IL-31 are the skin, lungs, intestines, and nervous system. IL-31 also has low expression levels in testes, bone marrow, thymus, spleen, kidneys, and skeletal muscles. Studies have shown that IL-31 plays an important role in allergic diseases such as dermatitis, itching, and allergic asthma.
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Reactivities: |
Human |
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Target: |
IL-31RA |
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Clone: |
Nembio |
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Isotype: |
Human IgG2(C130S/R132K/E136G/S137G/C218S/H263Q/R350Q/Q414E/G441DEL/K442DEL)-kappa |
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Alternative Name: |
CIM 331,CIM331;interleukin 31 receptor subunit alpha, interleukin 31 receptor A |
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Recommend Isotype Controls: |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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