Anti-Human IL-17A Monoclonal Antibody
Anti-Human IL-17A Monoclonal Antibody
Clone: Ixebio Catalog#: AB5829
Description:
Interleukin-17A (IL-17A), commonly known as IL-17, was first discovered at the transcriptional level through a mouse T cell hybridoma. Several years later, researchers found that IL-17A is expressed in CD4+ T cells and can induce IL-6 in fibroblasts. Subsequently, more studies revealed that IL-17A is a major mediator of T cell communication with the hematopoietic system and overexpression in vivo leads to extramedullary granulopoiesis. In the 21st century, significant progress has been made in understanding IL-17A. Research has shown that Th17 cell lineage commitment is independent of traditional activation pathways such as STAT4 and STAT6, meaning that IL-17A and other inflammatory factors like IL-6 are not identical. IL-17A plays a key role in host defense against various microbial pathogens and tissue inflammation, making it an important target for drug discovery in treating various forms of autoimmune and inflammatory diseases.
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Reactivities: |
Human |
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Target: |
IL-17A |
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Clone: |
Ixebio |
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Isotype: |
Human IgG4(S228P)-kappa |
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Alternative Name: |
LY2439821;CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A |
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Recommend Isotype Controls: |
Anti-HEL Human IgG4(S228P)-Kappa Isotype control |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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