Anti-Human FGFR Monoclonal Antibody
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Anti-Human FGFR Monoclonal Antibody

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Anti-Human FGFR Monoclonal Antibody

Clone: Aprbio                     Catalog#: AB5667


The FGFR (Fibroblast Growth Factor Receptor) gene family has four members, FGFR1-FGFR4. When the ligand binds to FGFR, it causes a conformational change in FGFR, leading to its activation and dimerization. FGFR proteins are also part of the receptor tyrosine kinase family and are transmembrane proteins composed of three extracellular immunoglobulin-like domains D1-D3, a single-pass transmembrane domain, and a cytoplasmic tyrosine kinase domain. The linker between D1 and D2 is called the Acid box, and D1 and the Acid box form an autoinhibitory region. D2 and D3 are responsible for specific binding to ligands. FGFR1-FGFR3 have two forms due to alternative splicing of the D3 region: IIIb and IIIc. Currently, only one subtype, IIIc, has been found in FGFR4. When FGF binds to FGFRs, it activates and amplifies signal pathways and transmits signals downstream to Ras/Raf/MEK and PI3K-AKT pathways, thereby exerting specific biological functions.








Human IgG1(E356D/M358L)-Lambda2

Alternative Name:

BAY-1179470; BAY 1179470; Aprutumab ixadotin; BAY 1187982; 1634620-63-5; Fibroblast growth factor receptor 2; FGFR2.

Recommend Isotype Controls:

Anti-HEL Human IgG1(E356D/M358L)-Kappa Isotype control

Recommended Dilution Buffer:

ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives.




PBS, pH 7.4,Contains no stabilizers or preservatives


<1EU/mg ,Determined by LAL gel clotting assay


>95% Determined by SDS-PAGE


0.2 μM filtered

Expression System:



Protein A




2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage.

Protocol Information:

Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment.

Intended for research use only. Not for human, therapeutic, or diagnostic applications.

The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  

Copyright 2023. Humimmu LLC.  All Rights Reserved

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