Anti-Human CA9 Monoclonal Antibody
Anti-Human CA9 Monoclonal Antibody
Clone: Girbio Catalog#: AB5839
Description:
Carbonic anhydrase IX (CAIX, CA9) is a transmembrane protein composed of 459 amino acids, consisting of four domains: N-terminal polysaccharide like domain (PG), CA catalytic domain (CA), single helix transmembrane region, and short intracellular tail. The physiological effects of CAIX are usually related to acid-base balance and the transport of carbon dioxide and bicarbonate, which can regulate intracellular (pHi) and extracellular (pHe) pH balance and lead to hypoxia and acidic tumor microenvironment. The influence of extracellular microenvironment (hypoxia and pH) has been recognized as a key indicator of cancer progression. CAIX, as a key hypoxia inducible marker, is expressed in a limited number of healthy tissues, but is specifically overexpressed on the surface of the vast majority of hypoxic solid tumor cells.
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Reactivities: |
Human |
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Target: |
CA9 |
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Clone: |
Girbio |
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Isotype: |
Human IgG1(E356D/M358L)-kappa |
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Alternative Name: |
Chimeric-monoclonal-antibody-G250; Monoclonal antibody G250; Rencarex; WX-G250; 916138-87-9; Anti-human Carbonic anhydrase IX; Anti-human CA IX; carbonic anhydrase 9;CA9 |
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Recommend Isotype Controls: |
Anti-HEL Human IgG1(E356D/M358L)-Kappa Isotype control |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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