Anti-Human B7-H3 Monoclonal Antibody
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Anti-Human B7-H3 Monoclonal Antibody

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Anti-Human B7-H3 Monoclonal Antibody

Clone: Ombbio     Catalog#: AB5137


B7-H3 (CD276) is a type I transmembrane protein belonging to the B7 immune co stimulatory and co inhibitory family, and its ligand is not yet clear. In 2001, B7-H3 was first discovered and identified as a member of the B7 family. Meanwhile, it has also been confirmed that B7-H3 shares a 20% -27% similarity with other family members. The B7-H3 protein is encoded by the chromosome 15q24 gene and structurally consists of 316 amino acids covering the extracellular domain, transmembrane domain, and short intracellular domain. The intracellular domain of B7-H3 protein is very short, and there is no known signal motif. In addition, due to exon duplication, the human B7-H3 protein contains one or two identical pairs of extracellular domains, resulting in two subtypes: 2IgB7-H3 is composed of a pair of immunoglobulin variable region (IgV) like and immunoglobulin constant region (IgC) like extracellular domains. 4IgB7-H3 contains two identical IgV like and IgC like extracellular domains, and is also the main subtype in human cells.









Human IgG1(K214R)-kappa

Alternative Name:

Burtomab. 8H9. B7H3. CD276. CD276 Molecule. 4Ig-B7-H3. B7RP-2. PSEC0249

Recommend Isotype Controls:

Anti-HEL Human IgG1 (K214R)-Kappa Isotype control

Recommended Dilution Buffer:

ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives.




PBS, pH 7.4,Contains no stabilizers or preservatives


<1EU/mg ,Determined by LAL gel clotting assay


>95% Determined by SDS-PAGE


0.2 μM filtered

Expression System:



Protein A




2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage.

Protocol Information:

Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment.


Intended for research use only. Not for human, therapeutic, or diagnostic applications.

The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  

Copyright 2023. Humimmu LLC.  All Rights Reserved

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