Anti-Human B7-H3 Monoclonal Antibody
Anti-Human B7-H3 Monoclonal Antibody
Clone: Ombbio Catalog#: AB5137
Description:
B7-H3 (CD276) is a type I transmembrane protein belonging to the B7 immune co stimulatory and co inhibitory family, and its ligand is not yet clear. In 2001, B7-H3 was first discovered and identified as a member of the B7 family. Meanwhile, it has also been confirmed that B7-H3 shares a 20% -27% similarity with other family members. The B7-H3 protein is encoded by the chromosome 15q24 gene and structurally consists of 316 amino acids covering the extracellular domain, transmembrane domain, and short intracellular domain. The intracellular domain of B7-H3 protein is very short, and there is no known signal motif. In addition, due to exon duplication, the human B7-H3 protein contains one or two identical pairs of extracellular domains, resulting in two subtypes: 2IgB7-H3 is composed of a pair of immunoglobulin variable region (IgV) like and immunoglobulin constant region (IgC) like extracellular domains. 4IgB7-H3 contains two identical IgV like and IgC like extracellular domains, and is also the main subtype in human cells.
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Reactivities: |
Human |
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Target: |
CD276 |
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Clone: |
Ombbio |
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Isotype: |
Human IgG1(K214R)-kappa |
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Alternative Name: |
Burtomab. 8H9. B7H3. CD276. CD276 Molecule. 4Ig-B7-H3. B7RP-2. PSEC0249 |
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Recommend Isotype Controls: |
Anti-HEL Human IgG1 (K214R)-Kappa Isotype control |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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