Anti-Human Ang-2 Monoclonal Antibody
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Anti-Human Ang-2 Monoclonal Antibody

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Anti-Human Ang-2 Monoclonal Antibody

Clone: Nesbio     Catalog#: AB5632


Angiopoietins are a family of vascular growth factors that are ligands for the tyrosine kinase receptor Tie-2. Angiopoietins acts primarily on the vasculature to control blood vessel development and stability. Four distinct angiopoietins have been described: Ang-1, Ang-2, Ang-3 and Ang-4. Structurally, the angiopoietins contain an N-terminal super clustering domain (SCD), a central coiled-coil domain (CCD) responsible for ligand homo-oligomerization, a linker region, and a C-terminal fibrinogen-related domain (FReD) required for binding to the Tie-2 receptor. Angiopoietins bind the second immunoglubulin motif of Tie-2 whereby they activate Tie-2 and, indirectly, Tie-1 in Tie-1/Tie-2 heterodimers. Angiopoietins (ANG1-ANG4) and the Tie-1/2 form an endothelial signalling pathway that is necessary for embryonic cardiovascular and lymphatic development. In adults, this system regulates vascular homeostasis, and controls vessel permeability, inflammation and angiogenic responses. Ang-1 and Ang-2 are the most exhaustively studied angiopoietins. Ang-1 is a critical player in vessel maturation and it mediates migration, adhesion and survival of endothelial cells. Ang-2 disrupts the connections between the endothelium and perivascular cells and promotes cell death and vascular regression.










Human IgG1(E356D/M358L)-kappa

Alternative Name:

REGN910; REGN-910; Anti-human Angiopoietin-2; Anti-human Ang-2; 1296818-77-3; Tie2 receptor antagonist

Recommend Isotype Controls:

Anti-HEL Human IgG1(E356D/M358L)-Kappa Isotype control

Recommended Dilution Buffer:

ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives.




PBS, pH 7.4,Contains no stabilizers or preservatives


<1EU/mg ,Determined by LAL gel clotting assay


>95% Determined by SDS-PAGE


0.2 μM filtered

Expression System:



Protein A




2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage.

Protocol Information:

Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment.


Intended for research use only. Not for human, therapeutic, or diagnostic applications.

The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  

Copyright 2023. Humimmu LLC.  All Rights Reserved

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