Anti Human 217 Position Phosphorylated Tau Protein (p-Tau217) Monoclonal Antibody
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Anti Human 217 Position Phosphorylated Tau Protein (p-Tau217) Monoclonal Antibody

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Anti Human 217 Position Phosphorylated Tau Protein (p-Tau217) Monoclonal Antibody

Anti Human 217 Position Phosphorylated Tau Protein (p-Tau217) Monoclonal Antibody

Clone HI564    Catalog#: A50564

Description: Phosphorylation of Tau proteins is a normal regulatory mechanism, but in neurodegenerative diseases such as Alzheimer’s disease (AD), Tau can become abnormally hyperphosphorylated. This hyperphosphorylation leads to the dissociation of Tau from microtubules, the formation of toxic aggregates known as neurofibrillary tangles, and the disruption of neuronal function. 
The phosphorylation of Tau at threonine 217 (T217) is one of the sites that are often modified in AD and other tauopathies. The phosphorylation at this site is thought to be particularly relevant to the pathogenesis of these diseases. Tau217 is considered a pathological phosphorylation site and has been found to correlate with the degree of cognitive impairment in AD patients.


Mouse IgG

Species reactivity:



Tissue culture


Protein A/G




Recombinant human p-Tau217 protein


Store at +4°C short term (1-2 weeks). Store at -20°C long term.


PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.




1. Lasagna-Reeves, C. A., & Kayed, R. (2012). Astrocytes as targets for the treatment of Alzheimer’s disease. Current Pharmaceutical Design, 18(36), 5891-5896.
2. Mocanu, M. M., & Popescu, B. O. (2018). The role of tau protein in the pathogenesis of Alzheimer’s disease. Journal of Alzheimer’s Disease, 64(3), 677-693.
3. Andreadaki, A., & Vekrellis, K. (2018). Tau-driven pathology in Alzheimer’s disease and related tauopathies: a critical review. Journal of Neurochemistry, 143(5), 595-608.

Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  
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