Anti Human Tau protein (hTau) Monoclonal Antibody
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Anti Human Tau protein (hTau) Monoclonal Antibody

A50562-100ug
Out of stock In stock
$699.00
$699.00

Anti Human Tau protein (hTau) Monoclonal Antibody

Clone HI562    Catalog#: A50562

Description: The Human Tau protein is a microtubule-associated protein (MAP) that is expressed in the brain and is involved in a variety of important cellular processes. It is encoded by the MAPT gene, which is located on chromosome 17.
Tau proteins play a critical role in maintaining the stability of microtubules, which are cylindrical structures that form the cytoskeleton of cells. Microtubules serve as tracks for the transport of various cellular materials, including neurotransmitter vesicles, which are essential for communication between nerve cells. In neurons, Tau proteins bind to microtubules and help to stabilize them, allowing for the proper formation and maintenance of the neuronal cytoskeleton. This stability is crucial for the structural integrity of neurons and for the efficient transport of materials within them. Tau proteins are also involved in other important processes, such as cell division, and have been found to play a role in the development of neurodegenerative diseases, such as Alzheimer's disease. In these diseases, Tau proteins can become abnormally phosphorylated, leading to the formation of aggregates called neurofibrillary tangles, which are a characteristic feature of the disease.

Isotype:

Mouse IgG

Species reactivity:

Mouse

Production:

Tissue culture

Purification:

Protein A/G

Applications:

ELISA, WB, IFA, IHC, CLIA, LFA, IP

Immunogen: 

Recombinant human Tau protein

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.

Clonality:

Monoclonal

 

Reference: 
1. Goedert, M., & Spillantini, M. G. (2006). A century of Alzheimer’s disease. Science, 314(5800), 777-781.
2. Lee, V. M., Goedert, M., & Trojanowski, J. Q. (1991). Neurodegenerative tauopathies. Neuron, 8(1), 15-35.
3. Mandelkow, E., & Mandelkow, E. M. (2012). Tau in Alzheimer’s disease and related tauopathies. Cold Spring Harbor perspectives in medicine, 2(10), a006247.


Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.  
Copyright 2024. Humimmu LLC.  All Rights Reserved

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